Understanding Ankylosing Spondylitis and Its Treatments

Ankylosing Spondylitis is characterized by inflammation that can lead to the fusion of the spine's vertebrae, resulting in reduced flexibility and potential disability. Treatments typically focus on reducing inflammation and managing symptoms. Symponi Aria (golimumab) is a biologic infusion therapy that targets specific pathways in the immune system to reduce inflammation Mayo Clinic.

Effects of Symponi Aria on Fitness and Muscle Health

While Symponi Aria is effective in managing the symptoms of AS, its impact on fitness and muscle health is a topic of interest. Some studies suggest that AS patients are at risk of early muscle loss, known as sarcopenia, which can affect overall fitness and muscle growth AS Patients at Risk of Early Muscle Loss - Ankylosing Spondylitis. However, Symponi Aria itself is not directly associated with weight gain or muscle loss, according to clinical trials Simponi and Simponi Aria side effects: How to manage them.

Muscle Changes and Recovery

Research indicates that muscle changes are common in AS patients, with alterations in muscle fiber size and strength being observed Muscle changes in ankylosing spondylitis. These changes can contribute to feelings of fatigue and reduced recovery post-exercise. Infusion therapies, while beneficial for reducing inflammation, may temporarily affect recovery times, as seen in anecdotal reports of fatigue following infusions What Not To Do After An Infusion - La Bella Medical Aesthetics.

Exercise and AS Management

Exercise remains a crucial component of managing AS. Regular physical activity can help maintain muscle mass and improve mobility. An intensive exercise program has been shown to significantly improve disease activity and reduce inflammatory markers in AS patients Clinical improvement and reduction in serum calprotectin levels after an intensive exercise programme for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis.