Measles Booster for Immunocompromised Individuals

For individuals who are immunocompromised, such as those on biologics, the administration of live vaccines like the measles, mumps, and rubella (MMR) vaccine is generally contraindicated. This is because live vaccines can pose a risk of causing infection in these individuals Cleveland Clinic CBS News. However, there are exceptions where the MMR vaccine may be recommended under specific conditions, such as for certain patients with HIV CDC.

The Role of Titer Tests

Before considering a booster, a measles titer test can be conducted to determine the presence of antibodies and assess immunity status. This test measures the level of IgG antibodies to ascertain if an individual is still protected against measles Request A Test Parade. If the titer test indicates low immunity, a healthcare provider may discuss the potential benefits and risks of receiving a booster, especially in the context of an outbreak CNN.

Research Insights

Recent studies have highlighted the importance of accurate antibody testing. For instance, a study found that certain immunoassays might show lower sensitivity for detecting measles antibodies, which could lead to false negatives PubMed. This underscores the need for reliable testing methods to ensure accurate immunity assessment.

Additionally, research has shown that high concentrations of measles neutralizing antibodies and high-avidity IgG are effective indicators of immunity and can help identify cases of reinfection NCBI.