Melatonin and Its Role in Neuroinflammation

Melatonin is recognized for its anti-inflammatory and antioxidant properties, which may be beneficial in managing neuroinflammation. Research indicates that melatonin can modulate the immune system and reduce inflammation by downregulating pro-inflammatory cytokines and oxidative stress markers Melatonin and inflammation-Story of a double-edged blade - PubMed. This makes it a potential therapeutic agent for conditions characterized by chronic inflammation, such as CFS.

Melatonin in Chronic Fatigue Syndrome

Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex disorder characterized by extreme fatigue and other symptoms that are not improved by rest. Studies have shown that melatonin may improve symptoms of CFS by enhancing sleep quality and reducing fatigue severity Melatonin for Chronic Fatigue Syndrome and Fibromyalgia. Additionally, melatonin's ability to regulate circadian rhythms and its neuroprotective effects could further support its use in CFS management The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders - PubMed.

Daytime Use of Melatonin

While melatonin is typically used to aid sleep, its daytime use for neuroinflammation and CFS is being explored. Some studies suggest that melatonin can be beneficial during the day due to its anti-inflammatory effects, which may help alleviate symptoms of CFS and related conditions Melatonin could be a potential therapy for long-COVID symptoms. However, the optimal dosage and timing for daytime use remain subjects of ongoing research.

Real-Life Experiences

There is limited anecdotal evidence available regarding the daytime use of melatonin for CFS. Some individuals report improvements in fatigue and cognitive function, while others experience no significant changes. The variability in responses highlights the need for personalized approaches and further clinical studies to establish standardized guidelines for melatonin use in CFS Associations between Melatonin, Neuroinflammation, and Brain ....