Patient Experiences with Nortriptyline for IBS

Many patients have shared their experiences with Nortriptyline for IBS on various platforms. According to user reviews on Drugs.com, Nortriptyline has an average rating of 8.2 out of 10 for the treatment of IBS, with 80% of reviewers reporting a positive experience and 11% reporting a negative one Nortriptyline for Irritable Bowel Syndrome User Reviews. Users have noted improvements in symptoms such as abdominal pain and diarrhea, which are common in IBS.

On forums like Reddit, individuals have shared personal stories about using Nortriptyline for IBS-D (diarrhea-predominant IBS). Some users reported significant relief from symptoms, while others experienced side effects such as drowsiness and dry mouth My Nortriptyline Experience for IBS-D : r/ibs - Reddit.

Scientific Research on Nortriptyline for IBS

While there is limited direct research on Nortriptyline specifically for IBS, studies on tricyclic antidepressants (TCAs) like Amitriptyline provide some insights. A meta-analysis found that TCAs significantly improve IBS symptoms compared to placebo, suggesting potential benefits for Nortriptyline as well Efficacy of tricyclic antidepressants in irritable bowel syndrome: A meta-analysis.

A study on the use of low-dose Amitriptyline, a similar TCA, showed it to be effective as a second-line treatment for IBS, with improvements in symptom severity and tolerability Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial.

Side Effects and Considerations

Common side effects of Nortriptyline include drowsiness, dry mouth, and constipation. These side effects are typical of TCAs and may vary in intensity among individuals. It is important for patients to discuss potential side effects and their management with healthcare providers before starting treatment.